Always inform your doctor or pharmacist about all medications you are taking, including over-the-counter drugs, herbal remedies, and supplements. This helps prevent potentially harmful interactions.
Drugs Affecting Domperidone Metabolism
Certain medications can affect how your body processes domperidone. Strong CYP3A4 inhibitors, like ketoconazole and some antifungals, increase domperidone levels, potentially leading to side effects. Conversely, strong inducers like rifampicin can decrease domperidone’s effectiveness. Discuss these interactions with your healthcare provider.
Drugs Influenced by Domperidone
Domperidone may interact with medications metabolized by the same liver enzymes. For instance, concurrent use with certain antiarrhythmics might require dose adjustments. Your doctor should carefully monitor you if you’re taking such medications alongside domperidone.
Specific Drug Interactions
| Antibiotics (Macrolides) | Erythromycin, Clarithromycin | Increased domperidone levels |
| Antifungal Agents | Ketoconazole, Itraconazole | Increased domperidone levels; increased risk of side effects |
| Antipsychotics | Haloperidol, Chlorpromazine | Potential additive effects on movement disorders |
Monitoring and Precautions
Regular monitoring by your doctor is crucial when taking domperidone, particularly if you are also taking other medications. Report any new or worsening symptoms immediately. Remember, this information is not exhaustive and doesn’t replace professional medical advice. Always consult your physician before starting or stopping any medication.
Further Information
Seek further clarification from your doctor or pharmacist if you have any questions or concerns regarding potential drug interactions with domperidone.
