Prilosec (omeprazole) can reduce the absorption of some medications, including Z-Pack (azithromycin). This interaction is not always significant, but it’s important to be aware of it.
How Does This Interaction Occur?
Prilosec decreases stomach acid. Azithromycin, like many antibiotics, needs a slightly acidic environment for optimal absorption. By lowering stomach acid, Prilosec can potentially reduce how much azithromycin your body absorbs. This doesn’t mean the antibiotic becomes completely ineffective, but it might be less potent.
What Are the Potential Consequences?
A lower azithromycin level could lead to less effective treatment of your infection. You might experience a slower recovery or the infection may not clear up completely.
What Should You Do?
Talk to your doctor or pharmacist. They can assess your specific situation and determine if the potential interaction is a significant concern for you. They may adjust your medication schedule or consider alternative medications.
Medication Timing Recommendations
While there’s no single perfect solution for everyone, generally spacing out the times you take Prilosec and Z-Pack can help. Discuss specific timing recommendations with your healthcare provider.
| Prilosec (Omeprazole) | Reduced azithromycin absorption | Consult your doctor or pharmacist |
| Z-Pack (Azithromycin) | Potential reduced effectiveness if Prilosec reduces absorption | Follow prescribed dosage and timing |
When to Contact Your Doctor
Contact your doctor if your infection symptoms don’t improve or worsen after starting the antibiotic. Report any new or unusual side effects you experience.
