Trazodone can interact with several medications, potentially altering their effects or causing adverse reactions. Always inform your doctor of all medications, supplements, and herbal remedies you are taking before starting Trazodone.
Central Nervous System Depressants: Combining Trazodone with other CNS depressants, such as benzodiazepines (e. g., diazepam, alprazolam), opioids (e. g., morphine, oxycodone), or alcohol, significantly increases the risk of sedation, respiratory depression, and even coma. Avoid concurrent use whenever possible.
Serotonergic Drugs: Using Trazodone with other serotonergic medications, including selective serotonin reuptake inhibitors (SSRIs, such as fluoxetine, sertraline), serotonin-norepinephrine reuptake inhibitors (SNRIs, such as venlafaxine, duloxetine), or monoamine oxidase inhibitors (MAOIs), can lead to serotonin syndrome, a potentially life-threatening condition characterized by agitation, confusion, muscle rigidity, and fever. Careful monitoring is crucial if concomitant use is unavoidable.
Antihypertensives: Trazodone may potentiate the hypotensive effects of certain antihypertensive medications, leading to dizziness and fainting. Your doctor may need to adjust your blood pressure medications accordingly.
CYP3A4 Inhibitors: Medications that inhibit the CYP3A4 enzyme (e. g., ketoconazole, erythromycin) can increase Trazodone blood levels, potentially intensifying its side effects. Your doctor might adjust your Trazodone dosage if necessary.
Warfarin: Concomitant use of Trazodone and Warfarin can increase the risk of bleeding. Close monitoring of your INR (International Normalized Ratio) is essential.
This information is not exhaustive. Discuss all potential drug interactions with your healthcare provider to ensure your safety and optimal treatment.
