Imipramine primarily treats incontinence by affecting the nervous system. It works as a tricyclic antidepressant, but its impact on urinary control stems from its ability to block the reuptake of norepinephrine and serotonin. This increased availability of these neurotransmitters strengthens the urethral sphincter’s muscle contractions, improving its ability to prevent urine leakage.
Norepinephrine’s Role
Specifically, the norepinephrine influence is key. This neurotransmitter enhances the tone and contractility of the sphincter, leading to better bladder control. A stronger sphincter means less involuntary urination.
Serotonin’s Contribution
While the norepinephrine effect is more prominent, serotonin also plays a role. Its impact is less understood but likely contributes to overall bladder function regulation, helping maintain the balance needed to prevent incontinence.
Important Considerations
Remember: Imipramine is not a first-line treatment for incontinence. It’s often prescribed when other methods fail. Consult a doctor to discuss potential side effects and appropriate usage. Side effects can include dry mouth, constipation, and drowsiness. The dosage and suitability of imipramine are determined on a case-by-case basis.
