Prednisone, a corticosteroid, increases the metabolism of vitamin K-dependent clotting factors. This happens because prednisone induces hepatic enzymes, specifically the cytochrome P450 system, which are responsible for breaking down these factors.
Reduced levels of these clotting factors lead to a lower INR (International Normalized Ratio). This means the blood clots slower, potentially increasing the risk of bleeding, especially in patients on anticoagulant medications like warfarin.
The extent of INR reduction varies depending on the prednisone dose and duration of treatment, as well as individual patient factors like liver function and genetics. Higher prednisone doses and longer treatment periods generally result in a more pronounced decrease in INR.
Regular INR monitoring is crucial when using prednisone concurrently with warfarin. Your doctor might need to adjust your warfarin dose to maintain a therapeutic INR range and prevent bleeding complications. Close collaboration with your healthcare provider is vital for safe and effective management of your anticoagulation therapy.
Always inform your doctor and pharmacist about all medications you are taking, including over-the-counter drugs and supplements, to avoid potentially harmful drug interactions. This proactive approach ensures your safety and helps optimize treatment outcomes.
