Terramycin contains oxytetracycline, a broad-spectrum antibiotic targeting Paenibacillus larvae, the bacterium causing American Foulbrood (AFB) in honeybee colonies. Oxytetracycline disrupts bacterial protein synthesis.
Oxytetracycline’s Mode of Action
Specifically, oxytetracycline binds to the 30S ribosomal subunit of the P. larvae bacteria. This binding inhibits the addition of amino acids to the growing polypeptide chain during translation, effectively halting protein production.
Without functional proteins, the bacteria cannot reproduce or perform vital functions, leading to their demise. This bacteriostatic effect, where bacterial growth is slowed but not immediately killed, is crucial for AFB treatment.
Dosage and Administration Considerations
Dosage and application methods vary depending on the severity of the infestation and the size of the colony. Always follow label instructions meticulously. Incorrect usage can lead to antibiotic resistance.
| Dosage | Consult the Terramycin product label for precise instructions based on colony size and infection level. |
| Application | Follow manufacturer guidelines for proper mixing and application to ensure even distribution within the hive. |
| Monitoring | Regularly inspect your hives for signs of AFB after treatment. Early detection of recurrence is key. |
Resistance Management
To prevent the development of oxytetracycline-resistant strains of P. larvae, limit the use of Terramycin. Explore alternative control measures such as hive sanitation and requeening.
