Metformin primarily tackles insulin resistance, a hallmark of PCOS. High insulin levels interfere with the ovaries’ ability to produce and release eggs, hindering ovulation. Metformin lowers insulin levels, thus improving the body’s response to its own insulin.
This insulin-sensitizing effect leads to reduced androgen production. High androgens are another key player in PCOS, disrupting the hormonal balance needed for regular ovulation. By lowering androgens, Metformin creates a more favorable hormonal environment for egg maturation and release.
Specifically, studies show Metformin improves ovulation rates in PCOS patients by approximately 10-20%, increasing the chances of conception. However, response varies, influenced by factors like BMI and the severity of insulin resistance.
While Metformin enhances ovulation, it doesn’t guarantee pregnancy. Many women still require additional fertility treatments like clomiphene citrate or intrauterine insemination (IUI). Your doctor will tailor treatment based on your individual circumstances.
Common side effects include nausea, diarrhea, and abdominal discomfort, although these often lessen with time. Always discuss potential side effects and their management with your doctor before starting Metformin.
Regular blood tests monitor the effectiveness of Metformin and its impact on your hormone levels. This allows your doctor to adjust your dosage or consider other options if needed.
