Prednisone, a glucocorticoid, works by binding to receptors inside your cells. This binding influences gene expression, affecting how your body makes proteins. Specifically, it reduces inflammation by suppressing the immune system’s response.
This immune suppression, however, can impact muscle function. Prednisone can cause muscle weakness (myopathy) and muscle wasting (atrophy). It achieves this by affecting protein metabolism, leading to a breakdown of muscle proteins exceeding their synthesis.
Furthermore, prednisone interferes with calcium handling in muscle cells, potentially triggering muscle spasms or twitches. This effect stems from its influence on the delicate balance of electrolytes within muscle fibers.
The severity of muscle-related side effects varies. Factors like dosage, duration of treatment, and individual susceptibility play significant roles. Consult your doctor immediately if you experience concerning muscle symptoms while taking prednisone. They can help manage these side effects through adjustments to your treatment plan or supplementary therapies.
